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Mostaghel EA, Nelson PS. Intracrine androgen metabolism in prostate cancer progression: mechanisms of castration resistance and therapeutic implications. Best Pract Res Clin Endocrinol Metab. 2008 Apr;22(2):243-58. Review. PubMed PMID:18471783. Residual tissue androgens are consistently detected within the prostate tumors of castrate individuals and are thought to play a critical role in
