Articles Tagged ‘steroidogenesis’

14
Jul
2010

Exploiting Mechanisms of Response and Resistance to Next Generation Androgen Pathway Antagonists Co-Leaders: Elahe Mostaghel, M.D., Ph.D., Stephen Plymate, M.D. The efficacy of agents targeting the androgen receptor (AR) axis in men with castration-resistant prostate cancer (CRPC) may differ markedly based on tumor-specific differences in the induction of AR pathway components. A

01
Jun
2008

Montgomery RB, Mostaghel EA, Vessella R, Hess DL, Kalhorn TF, Higano CS, True LD, Nelson PS. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res. 2008 Jun 1;68(11):4447-54. PubMed PMID: 18519708. Therapy for advanced prostate cancer centers on suppressing systemic androgens and

22
Apr
2008

Mostaghel EA, Nelson PS. Intracrine androgen metabolism in prostate cancer progression: mechanisms of castration resistance and therapeutic implications. Best Pract Res Clin Endocrinol Metab. 2008 Apr;22(2):243-58. Review. PubMed PMID:18471783. Residual tissue androgens are consistently detected within the prostate tumors of castrate individuals and are thought to play a critical role in