Posts Tagged ‘senescent’

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

Coppé JP, Patil CK, Rodier F, Sun Y, Muñoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008 Dec 2;6(12):2853-68. PubMed PMID: 19053174. Cellular senescence suppresses cancer by arresting cell proliferation, essentially ...

Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis

Dean JP, Nelson PS. Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis. Br J Cancer. 2008 Jan 29;98(2):245-9. Epub 2008 Jan 8. Review. PubMed PMID: 18182995. Experimental evidence suggests that aging-associated alterations in the tissue microenvironment act to promote prostate carcinogenesis. In this review, we survey the ...