Articles Tagged ‘senescent’

02
Dec
2008

Coppé JP, Patil CK, Rodier F, Sun Y, Muñoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008 Dec 2;6(12):2853-68. PubMed PMID: 19053174. Cellular senescence suppresses cancer by arresting cell proliferation, essentially

29
Jan
2008

Dean JP, Nelson PS. Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis. Br J Cancer. 2008 Jan 29;98(2):245-9. Epub 2008 Jan 8. Review. PubMed PMID: 18182995. Experimental evidence suggests that aging-associated alterations in the tissue microenvironment act to promote prostate carcinogenesis. In this review, we survey the