Articles Tagged ‘OGX-427’

19
Jul
2010

Targeting SEMA3C in Castration Resistant Prostate Cancer Co-Leaders: Martin Gleave, M.D., Christopher Ong, Ph.D. We postulate that under selective pressures of castration and AR pathway inhibitor treatment, stress-activated networks increase SEMA3C activity to activate key RTK (c-Met, EGFR/ERBB2) and downstream (src, AKT, MAPK) pathways, including cross-talk and activation of the AR. Since