Posts Tagged ‘castration-resistant’

High dose testosterone therapy for castration resistant prostate cancer: could this really work

Peter Nelson, M.D., Member, FHCRC

Genomic strategy for targeting therapy in castration-resistant prostate cancer

Mendiratta P, Mostaghel E, Guinney J, Tewari AK, Porrello A, Barry WT, Nelson  PS, Febbo PG. Genomic strategy for targeting therapy in castration-resistant prostate cancer. J Clin Oncol. 2009 Apr 20;27(12):2022-9. Epub 2009 Mar 16. PubMed PMID: 19289629. PURPOSE: Despite treatments which lower circulating androgens, advanced prostate cancers often ...

Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion

Harris WP, Mostaghel EA, Nelson PS, Montgomery B; Medscape. Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion. Nat Clin Pract Urol. 2009 Feb;6(2):76-85. PubMed PMID: 19198621. Androgen deprivation therapy remains a critical component of treatment for men with advanced prostate cancer, and data support ...

Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth

Montgomery RB, Mostaghel EA, Vessella R, Hess DL, Kalhorn TF, Higano CS, True LD, Nelson PS. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res. 2008 Jun 1;68(11):4447-54. PubMed PMID: 18519708. Therapy for advanced prostate cancer centers on suppressing systemic androgens and ...

Intracrine androgen metabolism in prostate cancer progression: mechanisms of castration resistance and therapeutic implications

Mostaghel EA, Nelson PS. Intracrine androgen metabolism in prostate cancer progression: mechanisms of castration resistance and therapeutic implications. Best Pract Res Clin Endocrinol Metab. 2008 Apr;22(2):243-58. Review. PubMed PMID:18471783. Residual tissue androgens are consistently detected within the prostate tumors of castrate individuals and are thought to play a critical role in ...