Articles Tagged ‘AR’

Mechanisms by Which the Type 1 Insulin-like Growth Factor Inhibition Enhances the Effects of Castration on Prostate Cancer Project Leader: Stephen Plymate, M.D. Co-leader: Bruce Montgomery, M.D. The lethal phenotype of prostate cancer is termed androgen-independent (AI), because it develops following castration in the presence of very low levels of

Maximal Targeted Inhibition of Androgen Signaling for Prostate Cancer Therapy Project Leader: Peter Nelson, M.D. Co-leader: Paul Lange, M.D. Clinical and laboratory evidence continues to demonstrate that androgens and the androgen receptor (AR) are the best available targets for treating/preventing both early and advanced prostate cancer. Numerous clinical trials have