Articles Tagged ‘androgens’

14
Jul
2010

Exploiting Mechanisms of Response and Resistance to Next Generation Androgen Pathway Antagonists Co-Leaders: Elahe Mostaghel, M.D., Ph.D., Stephen Plymate, M.D. The efficacy of agents targeting the androgen receptor (AR) axis in men with castration-resistant prostate cancer (CRPC) may differ markedly based on tumor-specific differences in the induction of AR pathway components. A

30
Jun
2009

Mostaghel EA, Montgomery B, Nelson PS. Castration-resistant prostate cancer: Targeting androgen metabolic pathways in recurrent disease. Urol Oncol. 2009 May-Jun;27(3):251-7. PubMed PMID: 19414113. Emerging evidence suggests that despite testicular androgen ablation, residual androgens, likely of adrenal--though potentially of prostatic--origin, play a critical role in the progression of prostate cancer

22
Apr
2008

Mostaghel EA, Nelson PS. Intracrine androgen metabolism in prostate cancer progression: mechanisms of castration resistance and therapeutic implications. Best Pract Res Clin Endocrinol Metab. 2008 Apr;22(2):243-58. Review. PubMed PMID:18471783. Residual tissue androgens are consistently detected within the prostate tumors of castrate individuals and are thought to play a critical role in

20
Jan
2007
Prostate gland may be capable of buffering negative effects of TRT

In 1966, investigators at the University of Chicago won a Nobel Prize for their research on the relationship between male sex hormones, known as androgens, and prostate cancer. Forty years later, researchers are still working out the intricacies of that relationship. A