Abstracts

Alternative RNA splicing of the androgen receptor gene in prostate cancer

Xuesen Dong, MD, MSc, PhD, University of British Columbia, Vancouver Prostate Centre

Predicting response and resistance to AR-axis inhibition in castration resistant prostate cancer

Elahe Mostaghel, MD, PhD, Fred Hutchinson Cancer Research Center

Castration-resistant prostate cancer: targeting androgen metabolic pathways in recurrent disease

Mostaghel EA, Montgomery B, Nelson PS. Castration-resistant prostate cancer: Targeting androgen metabolic pathways in recurrent disease. Urol Oncol. 2009 May-Jun;27(3):251-7. PubMed PMID: 19414113. Emerging evidence suggests that despite testicular androgen ablation, residual androgens, likely of adrenal--though potentially of prostatic--origin, play a critical role in the progression of prostate cancer ...

Genomic strategy for targeting therapy in castration-resistant prostate cancer

Mendiratta P, Mostaghel E, Guinney J, Tewari AK, Porrello A, Barry WT, Nelson  PS, Febbo PG. Genomic strategy for targeting therapy in castration-resistant prostate cancer. J Clin Oncol. 2009 Apr 20;27(12):2022-9. Epub 2009 Mar 16. PubMed PMID: 19289629. PURPOSE: Despite treatments which lower circulating androgens, advanced prostate cancers often ...

Conserved gene expression programs integrate mammalian prostate development and tumorigenesis

Pritchard C, Mecham B, Dumpit R, Coleman I, Bhattacharjee M, Chen Q, Sikes RA, Nelson PS. Conserved gene expression programs integrate mammalian prostate development and tumorigenesis. Cancer Res. 2009 Mar 1;69(5):1739-47. Epub 2009 Feb 17. PubMed PMID: 19223557. Studies centered at the intersection of embryogenesis and carcinogenesis have identified ...