• Four Institutions Four Institutions

    The Pacific Northwest Prostate Cancer SPORE represents four northwest research institutions who are working together to cure cancer. These four institutions are all world class, and together create a formidable framework for research. Led by Seattle’s Fred Hutchinson Cancer Research Center, the four institutions include the Hutchinson Center, the University of Washington, the Vancouver Prostate Centre, and Oregon Health & Science University (OHSU) Knight Cancer Institute.

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  • Leading Research Leading Research

    Clinical and laboratory evidence continues to demonstrate that androgens and the androgen receptor (AR) are the best available targets for treating/preventing both early and advanced prostate cancer. Numerous clinical trials have been designed to interfere with the AR pathway, but few have actually assessed the effectiveness of the therapy by demonstrating maximal target interference.

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  • Patient Advocacy Patient Advocacy

    The mission of the Patient Advocacy Committee of the Pacific Northwest Prostate Cancer SPORE is to promote effective interaction and collaboration among investigators, patients and all who are concerned with prostate cancer. Thus the committee transmits the views of patients and members of support groups to investigators in the field of prostate cancer. Simultaneously it communicates to patients and support groups information about current research, especially clinical trials.

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  • We Are

Working together to discover a cure for prostate cancer

Translational Research

The PNW Prostate SPORE is focused on five main projects aimed at understanding how prostate cancer (PC) develops. These five projects involve molecular predictors of PC progression, targeting LSD1 in PC, targeting SEMA3C in CRPC, clinical development of therapeutic strategies, and targeting the AR axis in men with CRPC.

Research Support

Research projects of the PNW Prostate Cancer SPORE are supported by four core programs: clinical, biostatistics, tissue & specimen, and leadership & administration.

Developmental Programs

The PNW Prostate Cancer SPORE provides career enhancement opportunities, as well as developmental research (pilot project) opportunities for researchers.


The Pacific Northwest Prostate Cancer SPORE, one of eight Prostate Cancer SPOREs in the nation, represents a coordinated effort of four institutions working together toward a common goal of reducing morbidity and mortality associated with prostate cancer. This work begins with gaining a better understanding of this disease. Understanding how and why prostate cancer can turn deadly is key to developing therapies that may effectively treat men with recurrent or advanced prostate cancer, for which there is no cure. This 5-year grant was originally awarded in 2002, and has been competitively renewed three times, most recently in 2018. Its longevity speaks to the innovative and groundbreaking progress achieved by this team.


Patient Advocacy

The overall goal of the Patient Advocacy Committee of the Pacific Northwest Prostate Cancer SPORE is to convey patient opinion and feedback to investigators in order to promote and hasten research aimed at the diagnosis, prognosis, treatment and ultimately the prevention of prostate cancer.